The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase.

Pester O, Barrett PJ, Hornburg D, Hornburg P, Pröbstle R, Widmaier S, Kutzner C, Dürrbaum M, Kapurniotu A, Sanders CR, Scharnagl C, Langosch D
J Am Chem Soc. 2013 135 (4): 1317-29

PMID: 23265086 · PMCID: PMC3560327 · DOI:10.1021/ja3112093

MeSH Terms (4)

Amyloid beta-Peptides Amyloid Precursor Protein Secretases Models, Molecular Thermodynamics

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