Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode.

Digby GJ, Utley TJ, Lamsal A, Sevel C, Sheffler DJ, Lebois EP, Bridges TM, Wood MR, Niswender CM, Lindsley CW, Conn PJ
ACS Chem Neurosci. 2012 3 (12): 1025-36

PMID: 23259038 · PMCID: PMC3526969 · DOI:10.1021/cn300103e

MeSH Terms (11)

Allosteric Regulation Allosteric Site Animals Benzamides Biphenyl Compounds CHO Cells Cricetinae Ligands Muscarinic Agonists Rats Receptor, Muscarinic M1

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