Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease.

Bajpai P, Sangar MC, Singh S, Tang W, Bansal S, Chowdhury G, Cheng Q, Fang JK, Martin MV, Guengerich FP, Avadhani NG
J Biol Chem. 2013 288 (6): 4436-51

PMID: 23258538 · PMCID: PMC3567693 · DOI:10.1074/jbc.M112.402123

MeSH Terms (16)

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Adrenergic alpha-Antagonists Animals Cell Line Cytochrome P-450 CYP2D6 Dopamine Agents Dopaminergic Neurons Dynamins Humans Mice Mitochondria Mitochondrial Proteins Parkinsonian Disorders Quinidine Reactive Oxygen Species Ubiquitin-Protein Ligases

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