Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.

Friberg A, Vigil D, Zhao B, Daniels RN, Burke JP, Garcia-Barrantes PM, Camper D, Chauder BA, Lee T, Olejniczak ET, Fesik SW
J Med Chem. 2013 56 (1): 15-30

PMID: 23244564 · PMCID: PMC3646517 · DOI:10.1021/jm301448p

MeSH Terms (16)

Antineoplastic Agents bcl-X Protein Crystallography, X-Ray Databases, Factual Drug Design Humans Indoles Ligands Magnetic Resonance Spectroscopy Molecular Docking Simulation Molecular Structure Myeloid Cell Leukemia Sequence 1 Protein Protein Binding Proto-Oncogene Proteins c-bcl-2 Small Molecule Libraries Structure-Activity Relationship

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