Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease.

Jacobs J, Grum-Tokars V, Zhou Y, Turlington M, Saldanha SA, Chase P, Eggler A, Dawson ES, Baez-Santos YM, Tomar S, Mielech AM, Baker SC, Lindsley CW, Hodder P, Mesecar A, Stauffer SR
J Med Chem. 2013 56 (2): 534-46

PMID: 23231439 · PMCID: PMC3569073 · DOI:10.1021/jm301580n

MeSH Terms (10)

Acetamides Drug Discovery Magnetic Resonance Spectroscopy Models, Molecular Molecular Structure Protease Inhibitors SARS Virus Severe Acute Respiratory Syndrome Small Molecule Libraries Structure-Activity Relationship

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