Functional modeling in zebrafish demonstrates that the atrial-fibrillation-associated gene GREM2 regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm.

Müller II, Melville DB, Tanwar V, Rybski WM, Mukherjee A, Shoemaker MB, Wang WD, Schoenhard JA, Roden DM, Darbar D, Knapik EW, Hatzopoulos AK
Dis Model Mech. 2013 6 (2): 332-41

PMID: 23223679 · PMCID: PMC3597016 · DOI:10.1242/dmm.010488

MeSH Terms (24)

Amino Acid Sequence Amino Acid Substitution Animals Arrhythmias, Cardiac Atrial Fibrillation Bone Morphogenetic Proteins Cell Differentiation Cytokines Disease Models, Animal Female Gene Expression Regulation, Developmental Heart Atria Heart Rate Humans Intercellular Signaling Peptides and Proteins Male Mice Middle Aged Molecular Sequence Data Myocytes, Cardiac Organogenesis Pedigree Zebrafish Zebrafish Proteins

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