Development of an in vivo active, dual EP1 and EP3 selective antagonist based on a novel acyl sulfonamide bioisostere.

Downey JD, Saleh SA, Bridges TM, Morrison RD, Daniels JS, Lindsley CW, Breyer RM
Bioorg Med Chem Lett. 2013 23 (1): 37-41

PMID: 23218714 · PMCID: PMC3534858 · DOI:10.1016/j.bmcl.2012.11.046

MeSH Terms (13)

Animals Diabetes Mellitus Half-Life Humans Hypertension Mice Microsomes, Liver Pyridines Receptors, Prostaglandin E, EP1 Subtype Receptors, Prostaglandin E, EP3 Subtype Receptors, Thromboxane Structure-Activity Relationship Sulfonamides

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