Trastuzumab-resistant cells rely on a HER2-PI3K-FoxO-survivin axis and are sensitive to PI3K inhibitors.

Chakrabarty A, Bhola NE, Sutton C, Ghosh R, Kuba MG, Dave B, Chang JC, Arteaga CL
Cancer Res. 2013 73 (3): 1190-200

PMID: 23204226 · PMCID: PMC3563941 · DOI:10.1158/0008-5472.CAN-12-2440

MeSH Terms (17)

Animals Antibodies, Monoclonal, Humanized Antineoplastic Agents Drug Resistance, Neoplasm Female Forkhead Box Protein O1 Forkhead Box Protein O3 Forkhead Transcription Factors Humans Inhibitor of Apoptosis Proteins Mice Neoplastic Stem Cells Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Receptor, ErbB-2 Survivin Trastuzumab

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