Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism.

Sheffler DJ, Sevel C, Le U, Lovell KM, Tarr JC, Carrington SJ, Cho HP, Digby GJ, Niswender CM, Conn PJ, Hopkins CR, Wood MR, Lindsley CW
Bioorg Med Chem Lett. 2013 23 (1): 223-7

PMID: 23200253 · PMCID: PMC3525729 · DOI:10.1016/j.bmcl.2012.10.132

MeSH Terms (17)

Acetylcholine Allosteric Regulation Allosteric Site Animals Benzamides Benzimidazoles Calcium CHO Cells Cricetinae Cricetulus Humans Piperidines Rats Receptor, Muscarinic M1 Receptors, Muscarinic Structure-Activity Relationship Transfection

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