Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence.

Liu Y, Hawkins OE, Su Y, Vilgelm AE, Sobolik T, Thu YM, Kantrow S, Splittgerber RC, Short S, Amiri KI, Ecsedy JA, Sosman JA, Kelley MC, Richmond A
EMBO Mol Med. 2013 5 (1): 149-66

PMID: 23180582 · PMCID: PMC3569660 · DOI:10.1002/emmm.201201378

MeSH Terms (25)

Animals Antineoplastic Agents Ataxia Telangiectasia Mutated Proteins Aurora Kinases Azepines Benzazepines Cell Cycle Proteins Cell Line, Tumor Cell Proliferation Cellular Senescence Checkpoint Kinase 2 DNA-Binding Proteins DNA Damage Humans Melanoma, Experimental Mice Mice, Nude NF-kappa B Polyploidy Protein-Serine-Threonine Kinases Protein Kinase Inhibitors Pyrimidines Tumor Suppressor Protein p53 Tumor Suppressor Proteins Xenograft Model Antitumor Assays

Connections (9)

This publication is referenced by other Labnodes entities: