Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169.

Tarr JC, Turlington ML, Reid PR, Utley TJ, Sheffler DJ, Cho HP, Klar R, Pancani T, Klein MT, Bridges TM, Morrison RD, Blobaum AL, Xiang Z, Daniels JS, Niswender CM, Conn PJ, Wood MR, Lindsley CW
ACS Chem Neurosci. 2012 3 (11): 884-95

PMID: 23173069 · PMCID: PMC3503349 · DOI:10.1021/cn300068s

MeSH Terms (13)

Allosteric Regulation Alzheimer Disease Animals Cognition Drug Discovery Indoles Muscarinic Agonists Myotonin-Protein Kinase Neurons Protein-Serine-Threonine Kinases Rats Receptor, Muscarinic M1 Sulfones

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