Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.

Rook JM, Noetzel MJ, Pouliot WA, Bridges TM, Vinson PN, Cho HP, Zhou Y, Gogliotti RD, Manka JT, Gregory KJ, Stauffer SR, Dudek FE, Xiang Z, Niswender CM, Daniels JS, Jones CK, Lindsley CW, Conn PJ
Biol Psychiatry. 2013 73 (6): 501-9

PMID: 23140665 · PMCID: PMC3572342 · DOI:10.1016/j.biopsych.2012.09.012

MeSH Terms (13)

Allosteric Regulation Animals Dose-Response Relationship, Drug Excitatory Amino Acid Agonists HEK293 Cells Hippocampus Humans Male Niacinamide Picolinic Acids Rats Receptor, Metabotropic Glutamate 5 Seizures

Connections (7)

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