Identification of determinants required for agonistic and inverse agonistic ligand properties at the ADP receptor P2Y12.

Schmidt P, Ritscher L, Dong EN, Hermsdorf T, Cöster M, Wittkopf D, Meiler J, Schöneberg T
Mol Pharmacol. 2013 83 (1): 256-66

PMID: 23093496 · PMCID: PMC3533468 · DOI:10.1124/mol.112.082198

MeSH Terms (19)

Animals Chlorocebus aethiops CHO Cells COS Cells Cricetinae Cricetulus Cyclic AMP Databases, Factual Drug Inverse Agonism High-Throughput Screening Assays Humans Ligands Molecular Docking Simulation Mutation Purinergic P2Y Receptor Agonists Purines Receptors, Purinergic P2Y12 Saccharomyces cerevisiae Structure-Activity Relationship

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