The effects of ACTH on lung maturation in fetal lambs.

Sundell HW, Gray ME, Relier JP, Kovar IZ, Catterton WZ, Swift LL, Stahlman MT
Am J Pathol. 1979 97 (2): 393-410

PMID: 230741 · PMCID: PMC2042466

The ability of adrenocorticotrophic hormone (ACTH) to induce lung maturation was evaluated in fetal lambs. One member of 14 twin pairs between 114 and 138 days of gestation was infused intravenously with 0.5 mg ACTH over 5 days. The lungs of treated versus control lambs were judged more mature by morphologic criteria by the use of light and electron microscopy and by biochemical criteria by the use of lamellar-body-rich cell fractions. None of 5 premature lambs treated with ACTH and allowed to breathe showed evidence of hyaline membrane disease, while 3 untreated control lambs showed typical hyaline membranes.

MeSH Terms (14)

Adrenocorticotropic Hormone Animals Animals, Newborn Female Gestational Age Humans Hyaline Membrane Disease Infant, Newborn Infusions, Parenteral Lipids Lung Organ Size Pregnancy Sheep

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