Human correlates of provocative questions in pancreatic pathology.

McDonald OG, Maitra A, Hruban RH
Adv Anat Pathol. 2012 19 (6): 351-62

PMID: 23060061 · PMCID: PMC3487591 · DOI:10.1097/PAP.0b013e318273f998

Studies of cell lines and of animal models of pancreatic cancer have raised a number of provocative questions about the nature and origins of human pancreatic cancer and have provided several leads into exciting new approaches for the treatment of this deadly cancer. In addition, clinicians with little or no contact with human pathology have challenged the way that pancreatic pathology is practiced, suggesting that "genetic signals" may be more accurate than today's multimodal approach to diagnoses. In this review, we consider 8 provocative issues in pancreas pathology, with an emphasis on "the evidence derived from man."

MeSH Terms (13)

Adenocarcinoma Animals Cell Line Disease Models, Animal Drug Resistance, Neoplasm Epithelial-Mesenchymal Transition Evidence-Based Medicine Gene Expression Regulation, Neoplastic Humans Mice Neoplasm Invasiveness Pancreas Pancreatic Neoplasms

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