Thr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancer.

Nifoussi SK, Vrana JA, Domina AM, De Biasio A, Gui J, Gregory MA, Hann SR, Craig RW
PLoS One. 2012 7 (10): e47060

PMID: 23056582 · PMCID: PMC3467206 · DOI:10.1371/journal.pone.0047060

MeSH Terms (20)

Animals Antineoplastic Agents Apoptosis Blotting, Western Cell Line, Tumor CHO Cells Cisplatin Cricetinae Cytarabine Drug Resistance, Neoplasm Etoposide Flow Cytometry Glycogen Synthase Kinase 3 Humans Myeloid Cell Leukemia Sequence 1 Protein Phosphorylation Protein Stability Proto-Oncogene Proteins c-bcl-2 Threonine Vinblastine

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