Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system.

Kirkby NS, Lundberg MH, Harrington LS, Leadbeater PD, Milne GL, Potter CM, Al-Yamani M, Adeyemi O, Warner TD, Mitchell JA
Proc Natl Acad Sci U S A. 2012 109 (43): 17597-602

PMID: 23045674 · PMCID: PMC3491520 · DOI:10.1073/pnas.1209192109

MeSH Terms (13)

Animals Blotting, Western Cardiovascular System Cells, Cultured Cyclooxygenase 1 Cyclooxygenase 2 Endothelium, Vascular Epoprostenol Humans Immunohistochemistry Mice Mice, Inbred C57BL Mice, Knockout

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