Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission.

Freyer C, Cree LM, Mourier A, Stewart JB, Koolmeister C, Milenkovic D, Wai T, Floros VI, Hagström E, Chatzidaki EE, Wiesner RJ, Samuels DC, Larsson NG, Chinnery PF
Nat Genet. 2012 44 (11): 1282-5

PMID: 23042113 · PMCID: PMC3492742 · DOI:10.1038/ng.2427

MeSH Terms (15)

Animals DNA, Mitochondrial DNA-Directed DNA Polymerase DNA Polymerase gamma Female Fertility Genetic Heterogeneity Genome, Mitochondrial Germ-Line Mutation Mice Mice, Inbred C57BL Oocytes RNA RNA, Mitochondrial RNA, Transfer, Met

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