Publication

Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias.

Potet F, Lorinc AN, Chaigne S, Hopkins CR, Venkataraman R, Stepanovic SZ, Lewis LM, Days E, Sidorov VY, Engers DW, Zou B, Afshartous D, George AL, Campbell CM, Balser JR, Li M, Baudenbacher FJ, Lindsley CW, Weaver CD, Kupershmidt S
J Biol Chem. 2012 287 (47): 39613-25

PMID: 23033485 · PMCID: PMC3501040 · DOI:10.1074/jbc.M112.380162

MeSH Terms (17)

Animals Arrhythmias, Cardiac Dose-Response Relationship, Drug Drug Discovery ERG1 Potassium Channel Ether-A-Go-Go Potassium Channels HEK293 Cells Humans Muscle Proteins Myocardium Naphthyridines Phenethylamines Potassium Channel Blockers Pyridines Rabbits Structure-Activity Relationship Sulfonamides

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