Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations.

Flaherty KT, Infante JR, Daud A, Gonzalez R, Kefford RF, Sosman J, Hamid O, Schuchter L, Cebon J, Ibrahim N, Kudchadkar R, Burris HA, Falchook G, Algazi A, Lewis K, Long GV, Puzanov I, Lebowitz P, Singh A, Little S, Sun P, Allred A, Ouellet D, Kim KB, Patel K, Weber J
N Engl J Med. 2012 367 (18): 1694-703

PMID: 23020132 · PMCID: PMC3549295 · DOI:10.1056/NEJMoa1210093

MeSH Terms (19)

Adult Aged Antineoplastic Combined Chemotherapy Protocols Disease-Free Survival Drug Therapy, Combination Female Fever Humans Imidazoles Male MAP Kinase Signaling System Melanoma Middle Aged Mitogen-Activated Protein Kinase Kinases Mutation Oximes Proto-Oncogene Proteins B-raf Pyridones Pyrimidinones

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