Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence.

Sidique S, Dhanya RP, Sheffler DJ, Nickols HH, Yang L, Dahl R, Mangravita-Novo A, Smith LH, D'Souza MS, Semenova S, Conn PJ, Markou A, Cosford ND
J Med Chem. 2012 55 (22): 9434-45

PMID: 23009245 · PMCID: PMC3508153 · DOI:10.1021/jm3005306

MeSH Terms (17)

Administration, Oral Allosteric Regulation Animals Behavior, Animal Brain Glutamic Acid HEK293 Cells Humans Indoles Microsomes, Liver Molecular Structure Nicotine Rats Receptors, Metabotropic Glutamate Structure-Activity Relationship Tissue Distribution Tobacco Use Disorder

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