Failure of surgery and isotretinoin to relieve jaw immobilization in fibrodysplasia ossificans progressiva: report of two cases.

Crofford LJ, Brahim JS, Zasloff MA, Marini JC
J Oral Maxillofac Surg. 1990 48 (2): 204-8

PMID: 2299462 · DOI:10.1016/s0278-2391(10)80212-5

Two patients with fibrodysplasia ossificans progressiva who presented with jaw immobilization due to formation of bone between the maxilla and mandible were treated with surgical resection of their ectopic bone in conjunction with experimental, adjunctive medical therapy using isotretinoin. Both patients had recurrence of their ectopic ossification within 2 months of surgery. Surgery to remove joint-bridging ossifications in FOP is not recommended.

MeSH Terms (8)

Adolescent Child, Preschool Humans Isotretinoin Jaw Diseases Male Myositis Ossificans Recurrence

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