Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover.

Manka JT, Vinson PN, Gregory KJ, Zhou Y, Williams R, Gogi K, Days E, Jadhav S, Herman EJ, Lavreysen H, Mackie C, Bartolomé JM, Macdonald GJ, Steckler T, Daniels JS, Weaver CD, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Stauffer SR
Bioorg Med Chem Lett. 2012 22 (20): 6481-5

PMID: 22981332 · PMCID: PMC3755010 · DOI:10.1016/j.bmcl.2012.08.043

MeSH Terms (12)

Allosteric Regulation Allosteric Site Animals Antipsychotic Agents Ethers Humans Niacinamide Psychotic Disorders Rats Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate Structure-Activity Relationship

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