Wheezing and asthma are independent risk factors for increased sickle cell disease morbidity.

Glassberg JA, Chow A, Wisnivesky J, Hoffman R, Debaun MR, Richardson LD
Br J Haematol. 2012 159 (4): 472-9

PMID: 22966893 · PMCID: PMC3758903 · DOI:10.1111/bjh.12049

To assess the associations between a doctor diagnosis of asthma and wheezing (independent of a diagnosis of asthma) with sickle cell disease (SCD) morbidity, we conducted a retrospective review of Emergency Department (ED) visits to the Mount Sinai Medical Center for SCD between 1 January 2007 and 1 January 2011. Outcomes were ED visits for pain and acute chest syndrome. The cohort included 262 individuals, median age 23·8 years, (range: 6 months to 67·5 years). At least one episode of wheezing recorded on a physical examination was present in 18·7% (49 of 262). Asthma and wheezing did not overlap completely, 53·1% of patients with wheezing did not carry a diagnosis of asthma. Wheezing was associated with a 118% increase in ED visits for pain (95% confidence interval [CI]: 56-205%) and a 158% increase in ED visits for acute chest syndrome (95% CI: 11-498%). A diagnosis of asthma was associated with a 44% increase in ED utilization for pain (95% CI: 2-104%) and no increase in ED utilization for acute chest syndrome (rate ratio 1·00, 95%CI 0·41-2·47). In conclusion, asthma and wheezing are independent risk factors for increased painful episodes in individuals with SCD. Only wheezing was associated with more acute chest syndrome.

© 2012 Blackwell Publishing Ltd.

MeSH Terms (16)

Acute Chest Syndrome Adolescent Adult Aged Anemia, Sickle Cell Asthma Child Child, Preschool Humans Infant Middle Aged Morbidity Respiratory Sounds Retrospective Studies Risk Factors Young Adult

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