A chemically programmed antibody is a long-lasting and potent inhibitor of influenza neuraminidase.

Hayakawa M, Toda N, Carrillo N, Thornburg NJ, Crowe JE, Barbas CF
Chembiochem. 2012 13 (15): 2191-5

PMID: 22965667 · PMCID: PMC3517015 · DOI:10.1002/cbic.201200439

Programming an anti-flu strategy: A new and potent neuraminidase inhibitor that maintains long-term systemic exposure of an antibody and the therapeutic activity of the neuraminadase inhibitor zanamivir has been created. This strategy could provide a promising new class of influenza A drugs for therapy and prophylaxis, and validates enzyme inhibitors as programming agents in synthetic immunology.

Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

MeSH Terms (14)

Animals Antibodies, Monoclonal Antiviral Agents Click Chemistry Fructose-Bisphosphate Aldolase Humans Immunoconjugates Influenza, Human Influenza A virus Mice Models, Molecular Neuraminidase Orthomyxoviridae Infections Zanamivir

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