Depletion of the C. elegans NAC engages the unfolded protein response, resulting in increased chaperone expression and apoptosis.

Arsenovic PT, Maldonado AT, Colleluori VD, Bloss TA
PLoS One. 2012 7 (9): e44038

PMID: 22957041 · PMCID: PMC3434205 · DOI:10.1371/journal.pone.0044038

MeSH Terms (14)

Animals Caenorhabditis elegans Endoplasmic Reticulum Endoplasmic Reticulum Chaperone BiP Gene Expression Regulation, Developmental Heat-Shock Proteins Hot Temperature Intestinal Mucosa Lysosomes Molecular Chaperones RNA Interference Stress, Physiological Unfolded Protein Response Up-Regulation

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