Mammalian target of rapamycin inhibitors in organ transplantation: an unkept promise.

Langone AJ, Helderman JH
Chest. 2012 142 (3): 734-737

PMID: 22948577 · DOI:10.1378/chest.12-1247

The initial enthusiasm for the advent of a potentially nonnephrotoxic immunosuppressant has been muted by data unmasking nephrotoxicity of mammalian target of rapamycin inhibitors, including renal podocyte injury resulting in proteinuria. Adverse reactions, including anemia, thrombocytopenia, hyperlipidemia, and especially diabetogenesis, have limited its use to niche indications such as prevention or amelioration of malignancy in organ transplant. The class seems to be best used to address malignancy in organ allograft recipients and as a first-line therapy in lymphangioleiomyomatosis.

MeSH Terms (11)

Anemia Enzyme Inhibitors Humans Hyperlipidemias Immunosuppressive Agents Organ Transplantation Podocytes Proteinuria Risk Factors Thrombocytopenia TOR Serine-Threonine Kinases

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