Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.

Peifer M, Fernández-Cuesta L, Sos ML, George J, Seidel D, Kasper LH, Plenker D, Leenders F, Sun R, Zander T, Menon R, Koker M, Dahmen I, Müller C, Di Cerbo V, Schildhaus HU, Altmüller J, Baessmann I, Becker C, de Wilde B, Vandesompele J, Böhm D, Ansén S, Gabler F, Wilkening I, Heynck S, Heuckmann JM, Lu X, Carter SL, Cibulskis K, Banerji S, Getz G, Park KS, Rauh D, Grütter C, Fischer M, Pasqualucci L, Wright G, Wainer Z, Russell P, Petersen I, Chen Y, Stoelben E, Ludwig C, Schnabel P, Hoffmann H, Muley T, Brockmann M, Engel-Riedel W, Muscarella LA, Fazio VM, Groen H, Timens W, Sietsma H, Thunnissen E, Smit E, Heideman DA, Snijders PJ, Cappuzzo F, Ligorio C, Damiani S, Field J, Solberg S, Brustugun OT, Lund-Iversen M, Sänger J, Clement JH, Soltermann A, Moch H, Weder W, Solomon B, Soria JC, Validire P, Besse B, Brambilla E, Brambilla C, Lantuejoul S, Lorimier P, Schneider PM, Hallek M, Pao W, Meyerson M, Sage J, Shendure J, Schneider R, Büttner R, Wolf J, Nürnberg P, Perner S, Heukamp LC, Brindle PK, Haas S, Thomas RK
Nat Genet. 2012 44 (10): 1104-10

PMID: 22941188 · PMCID: PMC4915822 · DOI:10.1038/ng.2396

MeSH Terms (28)

Amino Acid Substitution Animals Cell Line, Tumor CREB-Binding Protein DNA Copy Number Variations DNA Mutational Analysis E1A-Associated p300 Protein Gene Expression Profiling Gene Regulatory Networks Genome, Human Genome-Wide Association Study Histone-Lysine N-Methyltransferase Humans Intercellular Signaling Peptides and Proteins Lung Neoplasms Mice Mice, Knockout Models, Molecular Mutation Myeloid-Lymphoid Leukemia Protein Nerve Tissue Proteins Oligonucleotide Array Sequence Analysis Polymorphism, Single Nucleotide Protein Processing, Post-Translational PTEN Phosphohydrolase Retinoblastoma Protein Small Cell Lung Carcinoma Tumor Suppressor Protein p53

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