Differential protein stability and ALK inhibitor sensitivity of EML4-ALK fusion variants.

Heuckmann JM, Balke-Want H, Malchers F, Peifer M, Sos ML, Koker M, Meder L, Lovly CM, Heukamp LC, Pao W, K├╝ppers R, Thomas RK
Clin Cancer Res. 2012 18 (17): 4682-90

PMID: 22912387 · DOI:10.1158/1078-0432.CCR-11-3260

MeSH Terms (24)

Adenocarcinoma Adenocarcinoma of Lung Anaplastic Lymphoma Kinase Animals Apoptosis Carcinoma, Non-Small-Cell Lung Cell Line, Tumor Cell Proliferation Crizotinib HSP90 Heat-Shock Proteins Humans Kinesin Lung Neoplasms Mice NIH 3T3 Cells Oncogene Proteins, Fusion Protein-Tyrosine Kinases Protein Kinase Inhibitors Protein Stability Pyrazoles Pyridines Pyrimidines Receptor Protein-Tyrosine Kinases Signal Transduction

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