Clinical translation of cell-based pharmacogenomic discovery.

Cox NJ, Gamazon ER, Wheeler HE, Dolan ME
Clin Pharmacol Ther. 2012 92 (4): 425-7

PMID: 22910437 · PMCID: PMC3664667 · DOI:10.1038/clpt.2012.115

The use of cell-based models has emerged as a promising means to discover and validate pharmacologic phenotype-genotype relationships. The availability of large-scale genome studies in both human and model systems is now allowing us an unprecedented opportunity to understand how well cell-based models identify clinically relevant genetic variants associated with drug response and toxicity. Here we review these studies and the emerging translational information.

MeSH Terms (9)

Animals Cell Line, Tumor Drug Discovery Genomics Genomics Humans Pharmacogenetics Polymorphism, Single Nucleotide Translational Medical Research

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