Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator.

Mattmann ME, Yu H, Lin Z, Xu K, Huang X, Long S, Wu M, McManus OB, Engers DW, Le UM, Li M, Lindsley CW, Hopkins CR
Bioorg Med Chem Lett. 2012 22 (18): 5936-41

PMID: 22910039 · PMCID: PMC3433560 · DOI:10.1016/j.bmcl.2012.07.060

MeSH Terms (11)

Animals Dose-Response Relationship, Drug Humans KCNQ1 Potassium Channel Molecular Structure Piperidines Rats Structure-Activity Relationship Substrate Specificity Thiazoles Tosyl Compounds

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