Enhancing integrin α1 inserted (I) domain affinity to ligand potentiates integrin α1β1-mediated down-regulation of collagen synthesis.

Shi M, Pedchenko V, Greer BH, Van Horn WD, Santoro SA, Sanders CR, Hudson BG, Eichman BF, Zent R, Pozzi A
J Biol Chem. 2012 287 (42): 35139-35152

PMID: 22888006 · PMCID: PMC3471707 · DOI:10.1074/jbc.M112.358648

MeSH Terms (20)

Amino Acid Substitution Animals Cell Line, Transformed Collagen Type IV Down-Regulation Enzyme Activation Extracellular Signal-Regulated MAP Kinases Humans Integrin alpha1beta1 Laminin Ligands MAP Kinase Signaling System Mice Mice, Mutant Strains Models, Molecular Mutation, Missense Nuclear Magnetic Resonance, Biomolecular Protein Binding Protein Biosynthesis Protein Structure, Tertiary

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