A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy.

Fan X, Brezski RJ, Fa M, Deng H, Oberholtzer A, Gonzalez A, Dubinsky WP, Strohl WR, Jordan RE, Zhang N, An Z
Breast Cancer Res. 2012 14 (4): R116

PMID: 22873525 · PMCID: PMC3680949 · DOI:10.1186/bcr3240

MeSH Terms (18)

Amino Acid Sequence Animals Antibodies, Monoclonal, Humanized Antibody-Dependent Cell Cytotoxicity Cell Line Disease Models, Animal Female Humans Matrix Metalloproteinases Mice Molecular Sequence Data Neoplasms Protein Binding Proteolysis Receptor, ErbB-2 Receptors, IgG Trastuzumab Xenograft Model Antitumor Assays

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