Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships.

Gregory KJ, Noetzel MJ, Rook JM, Vinson PN, Stauffer SR, Rodriguez AL, Emmitte KA, Zhou Y, Chun AC, Felts AS, Chauder BA, Lindsley CW, Niswender CM, Conn PJ
Mol Pharmacol. 2012 82 (5): 860-75

PMID: 22863693 · PMCID: PMC3477233 · DOI:10.1124/mol.112.080531

MeSH Terms (16)

Allosteric Regulation Allosteric Site Animals Calcium Glutamic Acid HEK293 Cells Humans Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Phosphorylation Point Mutation Radioligand Assay Rats Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate Structure-Activity Relationship

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