Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death.

Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, Brittnacher MJ, Fong C, Radey M, Ogohara C, Stark AL, Akey JM, Dolan ME, Wurfel MM, Miller SI
Proc Natl Acad Sci U S A. 2012 109 (35): E2343-52

PMID: 22837397 · PMCID: PMC3435171 · DOI:10.1073/pnas.1206701109

MeSH Terms (25)

Adult Aged Aged, 80 and over Animals Apoptosis Apoptosis Regulatory Proteins Bone Marrow Cells Caspase 1 Caspase 9 Deoxyadenosines Genetic Predisposition to Disease Genetic Variation HapMap Project HEK293 Cells Humans Methionine Mice Mice, Inbred C57BL Middle Aged Polymorphism, Single Nucleotide Quantitative Trait Loci Salmonella Infections Salmonella typhimurium Thionucleosides Young Adult

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