INK4a/ARF [corrected] inactivation with activation of the NF-κB/IL-6 pathway is sufficient to drive the development and growth of angiosarcoma.

Yang J, Kantrow S, Sai J, Hawkins OE, Boothby M, Ayers GD, Young ED, Demicco EG, Lazar AJ, Lev D, Richmond A
Cancer Res. 2012 72 (18): 4682-95

PMID: 22836752 · PMCID: PMC3459578 · DOI:10.1158/0008-5472.CAN-12-0440

MeSH Terms (16)

Animals Blotting, Western Disease Models, Animal Enzyme-Linked Immunosorbent Assay Flow Cytometry Hemangiosarcoma Humans I-kappa B Kinase Interleukin-6 Mice Mice, Knockout NF-kappa B Real-Time Polymerase Chain Reaction Signal Transduction Tissue Array Analysis Transcription Factor RelA

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