Inhibition of phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model.

Tsunoda T, Ota T, Fujimoto T, Doi K, Tanaka Y, Yoshida Y, Ogawa M, Matsuzaki H, Hamabashiri M, Tyson DR, Kuroki M, Miyamoto S, Shirasawa S
Mol Cancer. 2012 11: 46

PMID: 22830422 · PMCID: PMC3439292 · DOI:10.1186/1476-4598-11-46

MeSH Terms (20)

Apoptosis Cell Line, Tumor Cluster Analysis Colorectal Neoplasms Cyclic Nucleotide Phosphodiesterases, Type 4 Enzyme Activation Gene Expression Profiling Gene Expression Regulation, Neoplastic Genes, ras HCT116 Cells Humans Phosphodiesterase 4 Inhibitors Phosphorylation Proto-Oncogene Proteins c-akt Recurrence RNA Interference Rolipram Spheroids, Cellular Tight Junctions Tumor Cells, Cultured

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