Bioactive aldehyde-modified phosphatidylethanolamines.

Guo L, Davies SS
Biochimie. 2013 95 (1): 74-8

PMID: 22819995 · DOI:10.1016/j.biochi.2012.07.010

Lipid peroxidation generates a variety of lipid aldehydes, which have been recognized to modify protein and DNA, causing inflammation and cancer. However, recent studies demonstrate that phosphatidylethanolamine (PE) is a major target for these aldehydes, forming aldehyde-modified PEs (al-PEs) as a novel family of mediators for inflammation. This review summarizes our current understanding of these al-PEs, including formation, detection, structural characterization, physiological relevance and mechanism of action.

Copyright © 2012 Elsevier Masson SAS. All rights reserved.

MeSH Terms (9)

Aldehydes Endoplasmic Reticulum Endoplasmic Reticulum Stress Humans Lipid Peroxidation Molecular Structure Oxidative Stress Phosphatidylethanolamines Reactive Oxygen Species

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