BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors.

Dahlman KB, Xia J, Hutchinson K, Ng C, Hucks D, Jia P, Atefi M, Su Z, Branch S, Lyle PL, Hicks DJ, Bozon V, Glaspy JA, Rosen N, Solit DB, Netterville JL, Vnencak-Jones CL, Sosman JA, Ribas A, Zhao Z, Pao W
Cancer Discov. 2012 2 (9): 791-7

PMID: 22798288 · PMCID: PMC3449158 · DOI:10.1158/2159-8290.CD-12-0097

MeSH Terms (13)

Aged Cell Line, Tumor Genome, Human Humans Male MAP Kinase Kinase Kinases MAP Kinase Signaling System Melanoma Mutation Protein Kinase Inhibitors Proto-Oncogene Proteins B-raf Pyridones Pyrimidinones

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