Podocyte ACE2 protects against diabetic nephropathy.

Harris RC
Kidney Int. 2012 82 (3): 255-6

PMID: 22791320 · PMCID: PMC7112297 · DOI:10.1038/ki.2012.127

As new components of the renin-angiotensin system (RAS) are elucidated, our understanding of the complexities of their interactions also advances. Previous studies have determined that podocytes possess a local RAS that can generate angiotensin II. Podocytes have also been shown to express angiotensin-converting enzyme 2 (ACE2), which can decrease angiotensin II levels by generation of angiotensin-(1-7). Nadarajah et al. now show that increased podocyte ACE2 activity can attenuate the development of diabetic nephropathy.

MeSH Terms (7)

Angiotensin-Converting Enzyme 2 Animals Diabetic Nephropathies Humans Male Peptidyl-Dipeptidase A Podocytes

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