Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib.

Buckner FS, Bahia MT, Suryadevara PK, White KL, Shackleford DM, Chennamaneni NK, Hulverson MA, Laydbak JU, Chatelain E, Scandale I, Verlinde CL, Charman SA, Lepesheva GI, Gelb MH
Antimicrob Agents Chemother. 2012 56 (9): 4914-21

PMID: 22777048 · PMCID: PMC3421879 · DOI:10.1128/AAC.06244-11

MeSH Terms (19)

14-alpha Demethylase Inhibitors Administration, Oral Alkyl and Aryl Transferases Animals Chagas Disease Crystallography, X-Ray Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System Drug Administration Schedule Female Humans Mice Models, Molecular Nitroimidazoles Quinolones Structure-Activity Relationship Triazoles Trypanocidal Agents Trypanosoma cruzi

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