Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.

Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
Nature. 2012 487 (7408): 505-9

PMID: 22763448 · PMCID: PMC3724525 · DOI:10.1038/nature11249

MeSH Terms (22)

Antineoplastic Agents Breast Neoplasms Cell Line, Tumor Cell Survival Drug Resistance, Neoplasm Female Hepatocyte Growth Factor Humans Indoles Lapatinib Ligands Melanoma Mitogen-Activated Protein Kinases Phosphatidylinositol 3-Kinases Protein Kinase Inhibitors Proto-Oncogene Proteins B-raf Quinazolines Receptor, ErbB-2 Receptor Protein-Tyrosine Kinases Signal Transduction Sulfonamides Vemurafenib

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