Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012.

Melancon BJ, Utley TJ, Sevel C, Mattmann ME, Cheung YY, Bridges TM, Morrison RD, Sheffler DJ, Niswender CM, Daniels JS, Conn PJ, Lindsley CW, Wood MR
Bioorg Med Chem Lett. 2012 22 (15): 5035-40

PMID: 22749871 · PMCID: PMC3883446 · DOI:10.1016/j.bmcl.2012.06.018

MeSH Terms (13)

Animals Azabicyclo Compounds Azetidines Cytochrome P-450 Enzyme System Humans Molecular Probes Protein Binding Protein Isoforms Rats Receptor, Muscarinic M1 Structure-Activity Relationship Sulfonamides Thiadiazoles

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