Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models.

Digby GJ, Noetzel MJ, Bubser M, Utley TJ, Walker AG, Byun NE, Lebois EP, Xiang Z, Sheffler DJ, Cho HP, Davis AA, Nemirovsky NE, Mennenga SE, Camp BW, Bimonte-Nelson HA, Bode J, Italiano K, Morrison R, Daniels JS, Niswender CM, Olive MF, Lindsley CW, Jones CK, Conn PJ
J Neurosci. 2012 32 (25): 8532-44

PMID: 22723693 · PMCID: PMC3398407 · DOI:10.1523/JNEUROSCI.0337-12.2012

MeSH Terms (29)

Animals Arrestins Behavior, Animal Benzamides Biphenyl Compounds Brain Calcium Cell Line CHO Cells Corpus Striatum Cricetinae Cricetulus Extracellular Signal-Regulated MAP Kinases Extracellular Space Fear Gene Expression Profiling Hippocampus Humans Male Maze Learning Membrane Potentials Mice Mice, Inbred C57BL Muscarinic Agonists Phosphorylation Prefrontal Cortex Rats Rats, Sprague-Dawley Receptor, Muscarinic M1

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