The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers.

Diaz LA, Williams RT, Wu J, Kinde I, Hecht JR, Berlin J, Allen B, Bozic I, Reiter JG, Nowak MA, Kinzler KW, Oliner KS, Vogelstein B
Nature. 2012 486 (7404): 537-40

PMID: 22722843 · PMCID: PMC3436069 · DOI:10.1038/nature11219

MeSH Terms (15)

Antibodies, Monoclonal Colorectal Neoplasms DNA, Neoplasm Drug Resistance, Neoplasm ErbB Receptors Evolution, Molecular Genes, ras Humans Mutation Panitumumab Proto-Oncogene Proteins Proto-Oncogene Proteins p21(ras) ras Proteins Selection, Genetic Time Factors

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