The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5.

Morrison RD, Blobaum AL, Byers FW, Santomango TS, Bridges TM, Stec D, Brewer KA, Sanchez-Ponce R, Corlew MM, Rush R, Felts AS, Manka J, Bates BS, Venable DF, Rodriguez AL, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Emmitte KA, Daniels JS
Drug Metab Dispos. 2012 40 (9): 1834-45

PMID: 22711749 · PMCID: PMC3422546 · DOI:10.1124/dmd.112.046136

MeSH Terms (30)

Aldehyde Oxidase Allopurinol Animals Benzamides Biotransformation Chromatography, Liquid Enzyme Inhibitors Excitatory Amino Acid Antagonists Hepatocytes Humans Hydroxylation Injections, Intravenous Liver Macaca fascicularis Magnetic Resonance Spectroscopy Male Metabolic Clearance Rate Microsomes, Liver Models, Biological Molecular Structure Oxygen Isotopes Raloxifene Hydrochloride Rats Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate Species Specificity Tandem Mass Spectrometry Thiazoles Xanthine Oxidase

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