Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats.

D'Amore V, Santolini I, van Rijn CM, Biagioni F, Molinaro G, Prete A, Conn PJ, Lindsley CW, Zhou Y, Vinson PN, Rodriguez AL, Jones CK, Stauffer SR, Nicoletti F, van Luijtelaar G, Ngomba RT
Neuropharmacology. 2013 66: 330-8

PMID: 22705340 · PMCID: PMC3787880 · DOI:10.1016/j.neuropharm.2012.05.044

MeSH Terms (22)

Age Factors Animals Brain Waves Cerebral Cortex Disease Models, Animal Electroencephalography Epilepsy, Absence Excitatory Amino Acid Agonists Excitatory Amino Acid Antagonists Hydrolysis Male Motor Activity Niacinamide Phosphatidylinositol Phosphates Pyridines Rats Rats, Inbred Strains Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate Somatosensory Cortex Thiazoles Ventral Thalamic Nuclei

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