Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis, and causes pause-dependent Ca-triggered arrhythmia.

Schober T, Huke S, Venkataraman R, Gryshchenko O, Kryshtal D, Hwang HS, Baudenbacher FJ, Knollmann BC
Circ Res. 2012 111 (2): 170-9

PMID: 22647877 · PMCID: PMC3393041 · DOI:10.1161/CIRCRESAHA.112.270041

MeSH Terms (15)

Action Potentials Animals Arrhythmias, Cardiac Calcium Calcium Signaling Cytosol Homeostasis Humans Intracellular Fluid Mice Mice, Transgenic Mutation Myofibrils Protein Binding Up-Regulation

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