A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer.

Blättermann S, Peters L, Ottersbach PA, Bock A, Konya V, Weaver CD, Gonzalez A, Schröder R, Tyagi R, Luschnig P, Gäb J, Hennen S, Ulven T, Pardo L, Mohr K, Gütschow M, Heinemann A, Kostenis E
Nat Chem Biol. 2012 8 (7): 631-8

PMID: 22634634 · DOI:10.1038/nchembio.962

MeSH Terms (11)

Benzeneacetamides Benzothiazoles Biopolymers Calcium Cell Line Cyclic AMP GTP-Binding Proteins Humans Ligands Receptors, G-Protein-Coupled Signal Transduction

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