Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM.

Sheffler DJ, Wenthur CJ, Bruner JA, Carrington SJ, Vinson PN, Gogi KK, Blobaum AL, Morrison RD, Vamos M, Cosford ND, Stauffer SR, Daniels JS, Niswender CM, Conn PJ, Lindsley CW
Bioorg Med Chem Lett. 2012 22 (12): 3921-5

PMID: 22607673 · PMCID: PMC3365510 · DOI:10.1016/j.bmcl.2012.04.112

MeSH Terms (14)

Allosteric Regulation Cell Line Central Nervous System Drug Discovery Glutamic Acid Humans Microsomes, Liver Molecular Probes Permeability Piperidines Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate Sensitivity and Specificity Structure-Activity Relationship

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